Make sure that the usbb2k_api daemon is running - kb2kskype won't work without it!
You need to have the daemon running before starting the kb2kskype client part and you need skype to be running before starting kb2kskype as well, so preferably you
start usbb2k_api at boot time,
start up skype afterwards and
start the kb2kskype application last
When starting the kb2kskype client, your running Skype should pop up a question about allowing this program to talk to skype - click on yes and (hopefully) you will only have to answer this question the first time.
Second you must have skype loaded up and logged into your user account. In order to get the sound working you will need to go to tools->options->sound devices and set all three sound settings to your voip usb phone in the main skype window.